Molecular study of the perforin gene in familial hematological malignancies
Identifieur interne : 006088 ( Main/Exploration ); précédent : 006087; suivant : 006089Molecular study of the perforin gene in familial hematological malignancies
Auteurs : Rim El Abed [Tunisie] ; Violaine Bourdon [France] ; Ilia Voskoboinik [Australie] ; Halima Omri [Tunisie] ; Yosra Ben Youssef [Tunisie] ; Mohamed Adnene Laatiri [Tunisie] ; Laetitia Huiart [France] ; François Eisinger [France] ; Laetitia Rabayrol [France] ; Marc Frenay [France] ; Paul Gesta [France] ; Liliane Demange [France] ; Hélène Dreyfus [France] ; Valérie Bonadona [France] ; Catherine Dugast [France] ; Hélène Zattara [France] ; Laurence Faivre [France] ; Monia Zaier [Tunisie] ; Saloua Yacoub Jemni [Tunisie] ; Testsuro Noguchi [France] ; Hagay Sobol [France] ; Zohra Soua [Tunisie]Source :
- Hereditary Cancer in Clinical Practice [ 1731-2302 ] ; 2011.
Abstract
Perforin gene (
Url:
DOI: 10.1186/1897-4287-9-9
PubMed: 21936944
PubMed Central: 3197553
Affiliations:
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France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Eugène-Marquis, Rue de la Bataille Flandre-Dunkerque, Rennes 35042</wicri:regionArea><wicri:noRegion>35042</wicri:noRegion><wicri:noRegion>35042</wicri:noRegion></affiliation></author><author><name sortKey="Zattara, Helene" sort="Zattara, Helene" uniqKey="Zattara H" first="Hélène" last="Zattara">Hélène Zattara</name><affiliation wicri:level="1"><nlm:aff id="I11">Département de Génétique, Hôpital de la Timone, 264 Rue Saint-Pierre, Marseille, 13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique, Hôpital de la Timone, 264 Rue Saint-Pierre, Marseille, 13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><wicri:noRegion>13385</wicri:noRegion></affiliation></author><author><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><affiliation wicri:level="1"><nlm:aff id="I12">Centre de Génétique, Hôpital d'Enfants, CHU de Dijon, 1 boulevard Jeanne d'Arc, Dijon, 21079, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Génétique, Hôpital d'Enfants, CHU de Dijon, 1 boulevard Jeanne d'Arc, Dijon, 21079</wicri:regionArea><wicri:noRegion>21079</wicri:noRegion><wicri:noRegion>21079</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I13">Unité d'oncogénétique, Centre Georges François Leclerc, 1 rue du Professeur Marion, Dijon, 21034 Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d'oncogénétique, Centre Georges François Leclerc, 1 rue du Professeur Marion, Dijon, 21034 Cedex</wicri:regionArea><wicri:noRegion>21034 Cedex</wicri:noRegion><wicri:noRegion>21034 Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Zaier, Monia" sort="Zaier, Monia" uniqKey="Zaier M" first="Monia" last="Zaier">Monia Zaier</name><affiliation wicri:level="1"><nlm:aff id="I1">UR Biologie 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Sousse 4002, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002</wicri:regionArea><wicri:noRegion>Avenue Hamed Karoui; Sousse 4002</wicri:noRegion></affiliation></author><author><name sortKey="Bourdon, Violaine" sort="Bourdon, Violaine" uniqKey="Bourdon V" first="Violaine" last="Bourdon">Violaine Bourdon</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Voskoboinik, Ilia" sort="Voskoboinik, Ilia" uniqKey="Voskoboinik I" first="Ilia" last="Voskoboinik">Ilia Voskoboinik</name><affiliation wicri:level="1"><nlm:aff id="I3">Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, VIC 3002, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Cancer Cell Death Laboratory, Cancer Immunology Program, Peter MacCallum Cancer Centre, St Andrew's Place, East Melbourne, VIC 3002</wicri:regionArea><wicri:noRegion>VIC 3002</wicri:noRegion></affiliation></author><author><name sortKey="Omri, Halima" sort="Omri, Halima" uniqKey="Omri H" first="Halima" last="Omri">Halima Omri</name><affiliation wicri:level="1"><nlm:aff id="I4">Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Youssef, Yosra Ben" sort="Youssef, Yosra Ben" uniqKey="Youssef Y" first="Yosra Ben" last="Youssef">Yosra Ben Youssef</name><affiliation wicri:level="1"><nlm:aff id="I1">UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002</wicri:regionArea><wicri:noRegion>Avenue Hamed Karoui; Sousse 4002</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Laatiri, Mohamed Adnene" sort="Laatiri, Mohamed Adnene" uniqKey="Laatiri M" first="Mohamed Adnene" last="Laatiri">Mohamed Adnene Laatiri</name><affiliation wicri:level="1"><nlm:aff id="I4">Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Huiart, Laetitia" sort="Huiart, Laetitia" uniqKey="Huiart L" first="Laetitia" last="Huiart">Laetitia Huiart</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Rabayrol, Laetitia" sort="Rabayrol, Laetitia" uniqKey="Rabayrol L" first="Laetitia" last="Rabayrol">Laetitia Rabayrol</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Frenay, Marc" sort="Frenay, Marc" uniqKey="Frenay M" first="Marc" last="Frenay">Marc Frenay</name><affiliation wicri:level="1"><nlm:aff id="I5">Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, 06189 Cedex 2, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Antoine Lacassagne, 33 Avenue de Valombrose, Nice, 06189 Cedex 2</wicri:regionArea><wicri:noRegion>06189 Cedex 2</wicri:noRegion><wicri:noRegion>06189 Cedex 2</wicri:noRegion></affiliation></author><author><name sortKey="Gesta, Paul" sort="Gesta, Paul" uniqKey="Gesta P" first="Paul" last="Gesta">Paul Gesta</name><affiliation wicri:level="1"><nlm:aff id="I6">CHG Niort, 40 avenue Charles de Gaulle, Niort, 79021, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>CHG Niort, 40 avenue Charles de Gaulle, Niort, 79021</wicri:regionArea><wicri:noRegion>79021</wicri:noRegion><wicri:noRegion>79021</wicri:noRegion></affiliation></author><author><name sortKey="Demange, Liliane" sort="Demange, Liliane" uniqKey="Demange L" first="Liliane" last="Demange">Liliane Demange</name><affiliation wicri:level="1"><nlm:aff id="I7">Polyclinique de Courlancy, 38 Rue de Courlancy, Reims, 51100, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Polyclinique de Courlancy, 38 Rue de Courlancy, Reims, 51100</wicri:regionArea><wicri:noRegion>51100</wicri:noRegion><wicri:noRegion>51100</wicri:noRegion></affiliation></author><author><name sortKey="Dreyfus, Helene" sort="Dreyfus, Helene" uniqKey="Dreyfus H" first="Hélène" last="Dreyfus">Hélène Dreyfus</name><affiliation wicri:level="1"><nlm:aff id="I8">Institut Ste Catherine, 1750 chemin du Lavarin, Avignon, 84000, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Institut Ste Catherine, 1750 chemin du Lavarin, Avignon, 84000</wicri:regionArea><wicri:noRegion>84000</wicri:noRegion><wicri:noRegion>84000</wicri:noRegion></affiliation></author><author><name sortKey="Bonadona, Valerie" sort="Bonadona, Valerie" uniqKey="Bonadona V" first="Valérie" last="Bonadona">Valérie Bonadona</name><affiliation wicri:level="1"><nlm:aff id="I9">Unité de génétique Epidémiologique, Centre Léon Bérard Lyon, 28 rue Laennec, Lyon, 69373 Cedex 08, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité de génétique Epidémiologique, Centre Léon Bérard Lyon, 28 rue Laennec, Lyon, 69373 Cedex 08</wicri:regionArea><wicri:noRegion>69373 Cedex 08</wicri:noRegion><wicri:noRegion>69373 Cedex 08</wicri:noRegion></affiliation></author><author><name sortKey="Dugast, Catherine" sort="Dugast, Catherine" uniqKey="Dugast C" first="Catherine" last="Dugast">Catherine Dugast</name><affiliation wicri:level="1"><nlm:aff id="I10">Centre Eugène-Marquis, Rue de la Bataille Flandre-Dunkerque, Rennes 35042, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre Eugène-Marquis, Rue de la Bataille Flandre-Dunkerque, Rennes 35042</wicri:regionArea><wicri:noRegion>35042</wicri:noRegion><wicri:noRegion>35042</wicri:noRegion></affiliation></author><author><name sortKey="Zattara, Helene" sort="Zattara, Helene" uniqKey="Zattara H" first="Hélène" last="Zattara">Hélène Zattara</name><affiliation wicri:level="1"><nlm:aff id="I11">Département de Génétique, Hôpital de la Timone, 264 Rue Saint-Pierre, Marseille, 13385, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département de Génétique, Hôpital de la Timone, 264 Rue Saint-Pierre, Marseille, 13385</wicri:regionArea><wicri:noRegion>13385</wicri:noRegion><wicri:noRegion>13385</wicri:noRegion></affiliation></author><author><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><affiliation wicri:level="1"><nlm:aff id="I12">Centre de Génétique, Hôpital d'Enfants, CHU de Dijon, 1 boulevard Jeanne d'Arc, Dijon, 21079, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Centre de Génétique, Hôpital d'Enfants, CHU de Dijon, 1 boulevard Jeanne d'Arc, Dijon, 21079</wicri:regionArea><wicri:noRegion>21079</wicri:noRegion><wicri:noRegion>21079</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I13">Unité d'oncogénétique, Centre Georges François Leclerc, 1 rue du Professeur Marion, Dijon, 21034 Cedex, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité d'oncogénétique, Centre Georges François Leclerc, 1 rue du Professeur Marion, Dijon, 21034 Cedex</wicri:regionArea><wicri:noRegion>21034 Cedex</wicri:noRegion><wicri:noRegion>21034 Cedex</wicri:noRegion></affiliation></author><author><name sortKey="Zaier, Monia" sort="Zaier, Monia" uniqKey="Zaier M" first="Monia" last="Zaier">Monia Zaier</name><affiliation wicri:level="1"><nlm:aff id="I1">UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002</wicri:regionArea><wicri:noRegion>Avenue Hamed Karoui; Sousse 4002</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Service d'Hématologie Clinique, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Jemni, Saloua Yacoub" sort="Jemni, Saloua Yacoub" uniqKey="Jemni S" first="Saloua Yacoub" last="Jemni">Saloua Yacoub Jemni</name><affiliation wicri:level="1"><nlm:aff id="I14">Centre régional de transfusion sanguine de Sousse, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Centre régional de transfusion sanguine de Sousse, CHU F. Hached, Avenue Ibn El Jazzar, Sousse, 4000</wicri:regionArea><wicri:noRegion>4000</wicri:noRegion></affiliation></author><author><name sortKey="Noguchi, Testsuro" sort="Noguchi, Testsuro" uniqKey="Noguchi T" first="Testsuro" last="Noguchi">Testsuro Noguchi</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation wicri:level="1"><nlm:aff id="I2">Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département d'Oncologie Génétique, de Prévention et Dépistage, Institut Paoli-Calmettes, 232 Boulevard Sainte Marguerite, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I15">Université d'Aix Marseille II, Avenue de Luminy, Marseille, 13009, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université d'Aix Marseille II, Avenue de Luminy, Marseille, 13009</wicri:regionArea><wicri:noRegion>13009</wicri:noRegion><wicri:noRegion>13009</wicri:noRegion></affiliation></author><author><name sortKey="Soua, Zohra" sort="Soua, Zohra" uniqKey="Soua Z" first="Zohra" last="Soua">Zohra Soua</name><affiliation wicri:level="1"><nlm:aff id="I1">UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>UR Biologie moléculaire des leucémies et lymphomes - Faculté de Médecine de Sousse, Université de Sousse, Avenue Hamed Karoui; Sousse 4002</wicri:regionArea><wicri:noRegion>Avenue Hamed Karoui; Sousse 4002</wicri:noRegion></affiliation></author></analytic><series><title level="j">Hereditary Cancer in Clinical Practice</title><idno type="ISSN">1731-2302</idno><idno type="eISSN">1897-4287</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Perforin gene (<italic>PRF1</italic>) mutations have been identified in some patients diagnosed with the familial form of hemophagocytic lymphohistiocytosis (HLH) and in patients with lymphoma. The aim of the present study was to determine whether patients with a familial aggregation of hematological malignancies harbor germline perforin gene mutations. For this purpose, 81 unrelated families from Tunisia and France with aggregated hematological malignancies were investigated. The variants detected in the <italic>PRF1 </italic>coding region amounted to 3.7% (3/81). Two of the three variants identified were previously described: the p.Ala91Val pathogenic mutation and the p.Asn252Ser polymorphism. A new p.Ala 211Val missense substitution was identified in two related Tunisian patients. In order to assess the pathogenicity of this new variation, bioinformatic tools were used to predict its effects on the perforin protein structure and at the mRNA level. The segregation of the mutant allele was studied in the family of interest and a control population was screened. The fact that this variant was not found to occur in 200 control chromosomes suggests that it may be pathogenic. However, overexpression of mutated <italic>PRF1 </italic>in rat basophilic leukemia cells did not affect the lytic function of perforin differently from the wild type protein.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Grakoui, A" uniqKey="Grakoui A">A Grakoui</name></author><author><name sortKey="Bromley, Sk" uniqKey="Bromley S">SK Bromley</name></author><author><name sortKey="Sumen, C" uniqKey="Sumen C">C Sumen</name></author><author><name sortKey="Davis, Mm" uniqKey="Davis M">MM Davis</name></author><author><name sortKey="Shaw, As" uniqKey="Shaw A">AS Shaw</name></author><author><name sortKey="Allen, Pm" uniqKey="Allen P">PM Allen</name></author><author><name sortKey="Dustin, Ml" uniqKey="Dustin M">ML Dustin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stinchcombe, Jc" uniqKey="Stinchcombe J">JC Stinchcombe</name></author><author><name sortKey="Bossi, G" uniqKey="Bossi G">G 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last="Demange">Liliane Demange</name><name sortKey="Dreyfus, Helene" sort="Dreyfus, Helene" uniqKey="Dreyfus H" first="Hélène" last="Dreyfus">Hélène Dreyfus</name><name sortKey="Dugast, Catherine" sort="Dugast, Catherine" uniqKey="Dugast C" first="Catherine" last="Dugast">Catherine Dugast</name><name sortKey="Eisinger, Francois" sort="Eisinger, Francois" uniqKey="Eisinger F" first="François" last="Eisinger">François Eisinger</name><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><name sortKey="Faivre, Laurence" sort="Faivre, Laurence" uniqKey="Faivre L" first="Laurence" last="Faivre">Laurence Faivre</name><name sortKey="Frenay, Marc" sort="Frenay, Marc" uniqKey="Frenay M" first="Marc" last="Frenay">Marc Frenay</name><name sortKey="Gesta, Paul" sort="Gesta, Paul" uniqKey="Gesta P" first="Paul" last="Gesta">Paul Gesta</name><name sortKey="Huiart, Laetitia" sort="Huiart, Laetitia" uniqKey="Huiart L" first="Laetitia" last="Huiart">Laetitia Huiart</name><name sortKey="Noguchi, Testsuro" sort="Noguchi, Testsuro" uniqKey="Noguchi T" first="Testsuro" last="Noguchi">Testsuro Noguchi</name><name sortKey="Rabayrol, Laetitia" sort="Rabayrol, Laetitia" uniqKey="Rabayrol L" first="Laetitia" last="Rabayrol">Laetitia Rabayrol</name><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><name sortKey="Zattara, Helene" sort="Zattara, Helene" uniqKey="Zattara H" first="Hélène" last="Zattara">Hélène Zattara</name></country><country name="Australie"><noRegion><name sortKey="Voskoboinik, Ilia" sort="Voskoboinik, Ilia" uniqKey="Voskoboinik I" first="Ilia" last="Voskoboinik">Ilia Voskoboinik</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3197553
|texte= Molecular study of the perforin gene in familial hematological malignancies
}}
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